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These selected publications highlight the major themes of research at Mercy Perinatal. Further information on individual researchers and Obstetrics and Gynaecology Research at the University of Melbourne can be found here.

Proton pump Inhibitors decrease sFLT-1 and sENG secretion, decrease hypertension, and rescue endothelial dysfunction

Kenji Onda, Stephen Tong, Sally Beard, Natalie Binder, Masanaga Muto, Sevvandi N. Senadheera, Laura Parry, Mark Dilworth...
Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

Brownfoot FC, Hastie R, Hannan NJ, Cannon P, Tuohey L, Parry LJ, Senadheera S, Illanes SE, Kaitu’u-Lino TJ, Tong S. Amer...
A double-blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset preeclampsia (PIE Trial): study protocol.

Cluver C, Walker SP, Mol B, Theron GB, Hall DR, Hiscock R, Tong S. BMJ Open 2015; 28;5(20):e008211
Effects of Pravastatin on human placenta, endothelium and women with severe preeclampsia.

Brownfoot FC, Tong S, Hannan NJ, Binder NK, Walker SP, Cannon P, Hastie R, Onda K, Kaitu’u-Lino TJ. Hypertension 2015; 6...
Treatment of early-onset preeclampsia with continuous positive airway pressure.

Whitehead C, Tong S, Wilson D, Howard M, Walker SP. Obstetrics and Gynecology 2015; 5(1): 131.
Placental-specific sFlt-1 e15a protein is increased in preeclampsia, antagonises vascular endothelial growth factor signalling, and has anti-angiogenic activity.

Palmer KR, Kaitu’u-Lino TJ, Hastie R, Ye L, Binder N, Cannon P, Tuohey L, Johns TG, Shub A, Tong S. Hypertension 2015; 6...
Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

Brownfoot FC, Hastie R, Hannan NJ, Cannon P, Tuohey L, Parry LJ, Senadheera S, Illanes SE, Kaitu’u-Lino TJ, Tong S. Amer...
Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta.

Brownfoot FC, Tong S, Hannan NJ, Hastie R, Cannon P, Kaitu’u-Lino TJ. BMJ Pregnancy and Childbirth 2016; 16:117.
Effects of gefitinib, an epidermal growth factor receptor inhibitor, on human placental cell growth.

Nilsson UW, Johns TG, Wilmann T, Kaitu’u-Lino T, Whitehead C, Dimitriadis E, Menkhorst E, Saglam B, Gao Y, Greenall SA, ...
Combination gefitinib and methotrexate compared to methotrexate alone to treat ectopic pregnancy.

Skubisz MM, Horne AW, Johns TG, Nilsson UW, Duncan WC, Wallace EM, Crtichley HO, Tong S. Obstetrics and Gynecology 2013;...

Proton pump Inhibitors decrease sFLT-1 and sENG secretion, decrease hypertension, and rescue endothelial dysfunction

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

A double-blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset preeclampsia (PIE Trial): study protocol.

Effects of Pravastatin on human placenta, endothelium and women with severe preeclampsia.

Treatment of early-onset preeclampsia with continuous positive airway pressure.

Placental-specific sFlt-1 e15a protein is increased in preeclampsia, antagonises vascular endothelial growth factor signalling, and has anti-angiogenic activity.

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta.

Effects of gefitinib, an epidermal growth factor receptor inhibitor, on human placental cell growth.

Combination gefitinib and methotrexate compared to methotrexate alone to treat ectopic pregnancy.

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